* Xanax includes a boxed warning about the risk of severe damage or Demise if taken with opioids. A boxed warning is the most serious warning with the FDA. For more aspects, begin to see the “Xanax precautions” part down below.Digoxin. Digoxin (Lanoxin) is usually a heart medication. Using Xanax with digoxin may well lead to digoxin to construc